Surface engineering the cellular microenvironment via patterning and gradients

Surface Engineering the Cellular Microenvironment via Patterning and Gradients

Cell organization, proliferation, and differentiation are impacted by diverse cues present in the cellular microenvironment. As a result, the surface of a material plays an important role in cellular function. Synthetic surfaces may be augmented by physical as well as chemical means. In particular, patterning and interfacial gradients may be utilized to mitigate the cellular response. Patternin...

Patterning the cellular microenvironment.

Hydrogels and microtechnologies for engineering the cellular microenvironment.

Hydrogels represent a class of materials suitable for numerous biomedical applications such as tissue engineering and drug delivery. Hydrogels are by definition capable of absorbing large amount of fluid, making them adequate for cell seeding and encapsulation as well as for implantation because of their biocompatibility and excellent diffusion properties. They also possess other desirable prop...

Biofunctionalization of Hydrogels for Engineering the Cellular Microenvironment

14.2 Mimicking the ECM 317 14.2.1 Covalent immobilization of ECM-derived proteins and growth factors through reaction of amino acid side chains 319 14.2.2 Immobilization of growth factors through interactions with other biomolecules 322 14.2.3 Protein/peptide tags for immobilization 326 14.2.3.1 Collagen-binding domain-mediated immobilization 326 14.2.3.2 Factor XIIIA transglutaminase catalyzed...

20 Nanotechnology for Engineering Cellular Microenvironment and Gene Delivery

Tissue engineering aims at repairing and restoring lost tissue structure and functions caused by disease processes or traumatic events (Langer and Vacanti 1993). Driven by clinical demands, extensive research efforts have been dedicated toward regenerating a broad range of tissues, from the skin, cartilage, bone, and blood vessels to more complex organ-level systems such as the bladder. Most ti...